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A high-cholesterol diet can inhibit sterol regulatory element-binding protein 2 (SREBP2), promoting the endocytic degradation of tight junction proteins and worsening barrier function, highlighting the importance of metabolic regulation in maintaining the intestinal barrier [391]
2000, Katsura and Inui 2003)
(2024) 14:e70070
The researchers weren't sure why
It is, mechanistically, a direct intervention on the same signalling pathway that underlies the metabolic inflammation that made weight loss difficult in the first place
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