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However, metformin administration failed to rescue paw withdrawal thresholds or pain sensitivity in Nrf2 KO mice, unlike the protective effects observed in MIA-induced WT OA mice (Fig

doi: 10.1152/physrev.00025.2016

After carefully reviewing and screening, 23 articles [3, 728] were finally included in the meta-analysis

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ATMs have two main phenotypes: M1 macrophages (M1) is considered the culprit of AT inflammation, can participate in glycolysis to rapidly produce ATP, and plays a key role in the initiation and maintenance of systemic inflammation and insulin resistance