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Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial

2.6.5 Determination of the protein levels of endoplasmic reticulum stress markers by Western blotting and ELISA Protein levels of phosphorylated PERK and CHOP-10 proteins were determined in the homogenate of the liver tissue

PMID 28301903

Single-dose oral administration of EXEL-2880 resulted in prolonged inhibition of phosphorylation of constitutively phosphorylated Met in B16F10 solid tumors as well as ligand HGF-stimulated phosphorylation of Met in whole liver [78]

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