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Of interest, D-amino acid metabolism was the most prominent metabolic pathway in both co-metabolism and microbial metabolism, with a total of five involved metabolites, and was the most relevant pathway for CAG pathogenesis

Biomolecules Ther

10.1016/S1995-7645(13)60068-1 62 Jaja-ChimedzaA.ZhangL.WolffK.GrafB

however, there is no current literature to explain the relationship between GLP-1 and the AMPK signaling pathway

Therefore, targeting the Nrf2/ARE pathway represents a promising strategy to simultaneously address oxidative stress-induced neuronal dysfunction and the toxic proteinopathies characteristic of these disorders, offering hope for more effective treatments that modify disease progression rather than merely alleviating symptoms (Yang et al., 2025

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