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In agreement with our findings, recent genomic gene expression profiles by microarray analyses in a gene dose-response model of Nrf2-null model have revealed that graded activation of Nrf2 increased the transcription of a large number of genes involved in Nrf2-mediated oxidative stress response, glutathione metabolism, and xenobiotic metabolism, including several genes responsible for the reduction of superoxide ions using GSH, i.e., glutathione peroxidases Gpx2 and Gpx4 , which augmented by 2260 and 105%, respectively, in Keap1-HKO mice compared to WT mice (Wu et al., 2011)

(20) After 52 weeks, participants in both groups maintained their weight loss of 12% and BMC, CTX-1, and P1NP were measured again

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Additionally, this combination can cause skin irritation and dryness, especially for sensitive skin

(2016) 137:e20153684