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Clinical practice guidelines[20, 21] have recommended the use of SGLT2i in individuals at higher risk of HF, while GLP-1RA may be prioritized in those with T2DM at higher ASCVD risk (calculated 10-year ASCVD risk 10%, Class IIa, level of evidence: B) given their neutral effect on HF hospitalization [22]

If ultimately adopted by the FDA, today's advisory committee recommendation represents a significant step toward allowing U.S

Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, et al

Another double-blind clinical study26 also found that 10 g/day acacia gum likewise helped relieve constipation compared to placebo

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Second, head-to-head trials of various GLP-1 RA treatments (including more recent dual and triple agonists) with prospectively specified inflammatory and oxidative stress biomarker endpoints should be part of future comparative efficacy studies