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Other Therapeutic Approaches Reducing Iron In severe iron overload, other methods for reducing iron levels may be employed to prevent the incidence and progression of chronic diseases

In the SUMMIT trial, tirzepatide significantly reduced the risk of death from cardiovascular causes or worsening heart failure events in patients with heart failure with preserved ejection fraction (ejection fraction 50% and above) and obesity (BMI 30 kg/m 2 ), compared with placebo (HR 0.62

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Counterion Analysis Acetate, trifluoroacetate or another counterion may require separate measurement where composition matters