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Angiogenic peptides theoretically carry oncogenic risk in individuals with undetected malignancies, though this has not been documented in published animal studies

S2CID 36679018

Cyclophosphamide (Cytoxan) Cyclophosphamide (brand name Cytoxan) is a cytotoxic (toxic to living cells) agent that suppresses both red and white blood cells in the bone marrow

Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, et al

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Repeated strain on the ligament can cause collagen fibrils to undergo deformation, affecting their alignment and cross-linking patterns