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Because phentermine is a stimulant, it can raise blood pressure and heart rate which is why PEAK monitors these metrics at every follow-up visit

Past concerns included: Pancreatitis and pancreatic cancer Gallbladder issues Kidney injury Regulators like the FDA and European Medicines Agency (EMA) have required post-marketing surveillance and black box warnings on these medications, especially around thyroid cancer in animal studies

Considering the effect of SGLT1 inhibition on the intestinal microbiome as well as the direct effect of inhibition of SGLT1 expression in the heart and brain, there are several ways that SGLT1 inhibition could favorably alter the risk of thrombosis (Fig

doi: 10.4254/wjh.v12.i7.332

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