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Estimands are defined as targets of estimation based on the trial objectives, providing greater transparency of the effects reported [60]

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Obesity is associated with numerous comorbid conditions, notably non-communicable diseases including hypertension, type 2 diabetes (T2D), and cardiovascular disease (CVD) which contributed to a staggering five million deaths globally in 2019 ( 2 Method For this narrative review, most articles included were chosen from searches in PubMed and Google Scholar