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In the skin, ROS are generated continuously, however, they can be eliminated by a variety of antioxidant substrates (Richelle et al., 2006)

Several potential causes of eye floaters exist, including age-related vitreous shrinkage

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* Deaths are also included as serious AEs and discontinuations due to AEs

382 Furthermore, TAZ can also act as a co-activator of hypoxia-inducible factor-1 (HIF-1), which results in enhanced transcriptional activity of HIF-1