how do you wean off glp 1 Weight loss maintenance after discontinuing GLP-1 : r/Zepbound Coming off GLP 1s |

JAMA Intern Med 2024;184:1301-12.ArticlePubMedPMC 78

(Many people use Ozempic off label for weight loss, though it is not FDA-approved for such.) These medications seem to promote weight loss through two mechanisms that, again, mimic the action of endogenous GLP-1: They delay gastric emptying: The sensation of fullness caused by slower gastric emptying can prompt people to eat less, thus helping them lose weight over time

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Sublingual drop storage requirements Most compounded sublingual GLP-1 drops require refrigeration

These numbers explain why so many patients either give up on treatment or turn to compounded alternatives and discount programs

No other potential conflicts of interest relevant to this article were reported