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When semaglutide reduces your caloric intake, your body needs a reason to keep muscle

Common side effects in the central nervous system include: trouble sleeping mild anxiety feeling jittery or irritable Rare side effects include: fatigue extreme anxiety panic attacks mania hallucinations delusions feelings of paranoia Tell your doctor if you have a history of drug or alcohol use disorder

J Obes 2020: 6134362

Weight loss does improve certain PCOS symptoms, per a 2024 systematic review in Annals of Internal Medicine , but again, its extra tricky for those with the under-researched condition

As of mid-2026, retatrutide is investigational and has not been approved by the FDA or any other major regulatory agency

Its largely outdated now