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Key Safety Considerations Semaglutide is appropriate for adults with a BMI of 27 or higher (or 30+ for those without weight-related conditions) who have tried lifestyle changes and need additional support

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Exercise and lifestyle modification exert substantial antidepressant effects, especially for mild MDD (Marx et al., 2023)

Peripheral arterial disease , more prevalent in people with diabetes, can cause exertional calf pain (claudication), cold feet, absent pulses, and delayed healing

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The Gut, the Heart, and TMAO. August 1, 2016