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Furthermore, a study found that cyclodextrin (-CD) greatly increases the solubility of drugs in combinations comprising acidic non-steroidal anti-inflammatory drugs and basic H2 blockers such as indomethacin-imidazole, histidine-imidazole where the solubility of the drug is enhanced by the interaction between the drugs

they are research observations in laboratory models

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TNF induces matrix metalloproteinase-9 expression in monocytic cells through ACSL1/JNK/ERK/NF-kB signaling pathways