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An autopsy study has shown that patients with T2DM have decreased -cell mass compared with age- and body mass index-matched nondiabetic individuals [12]

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It doesn't happen instantaneously at a specific date it's a gradual degradation that accumulates over time with exposure to heat, moisture, light, and freeze-thaw cycles

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Acknowledgements The research conducted in this study received support from the collaborative project between National Tsing Hua University and Kaohsiung Medical University to Dr