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Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats

10.1038/onc.2011.250 95 XuJ.ChenF.ZhuW.ZhangW

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The concentration was 50 to 100 times lower than standard GHK-Cu serums (0.02% vs 1 to 2%), which likely explains the modest outcome

Some subjects may require 25-50% dose reductions to maintain acceptable side effect profiles

Extensions of indications were subject to the same timeframe as a de novo assessment