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Secondary endpoints included changes in CAT phlegm score at 4 and 8 weeks, total CAT score at 4, 8, and 12 weeks, and SGRQ-C at 4, 8, and 12 weeks of treatment compared to the baseline, the satisfaction score and compliance with NAC assessed at 12 weeks, and the association between the satisfaction score and changes in symptom scores
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This represents an emerging area requiring urgent investigation through longitudinal studies
Consider reduced dosing and careful monitoring of response
Vitamin C: Fact Sheet for Health Professionals
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