The USA is projected to record a 19.4% CAGR from 2026 to 2036 as coverage pathways and high treatment need create demand for coordinated support
There is also a compliance angle
In one trial of people with obesity and knee osteoarthritis, top-line results released in late 2025 showed that those receiving 12 mg weekly achieved 2226% average weight loss over 68 weeks , while the placebo group lost only around 2.5%
The Wegovy and Ozempic $25 savings cards require commercial insurance and do not work for the uninsured or for Medicare, Medicaid, or TRICARE
Advances in histopathology and integrated microbiological and molecular diagnostics are improving recognition where clinical cues are muted or misleading, with growing emphasis on the continuum between colonisation, superficial infection, and early invasive disease in this population
CLINICAL TRIAL EVIDENCE FOR GLP-1 RAs IN MASH Table 2 provides a summary of phase 2 and phase 3 studies examining GLP-1 RAs and dual or triple agonists (aiming glucagon, GIP, and GLP-1 receptors) in individuals with MASLD/MASH, where hepatic biopsies were used to evaluate liver outcomes [3,5,10,11,15,22-25,44-52]
