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In 2021, the Amgen team published the preclinical research progress of their dual-function molecule project AMG 133, which involves GIPR antibodies and GLP-1R, for the first time in "Cell Reports Medicine"

In the complex, importin- adopts a banana-shaped conformation in which its inner concave surface makes charge interactions with the second basic amino acid cluster of the NLS (Figure 2C)

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Using lean Vgat-ChR2 mice, we found that tesofensine reduces the feeding behavior induced by the optogenetic activation of LH GABAergic neurons ( Fig 4 )

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