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Finally, similar to GLP-1 RAs, the medication should not be used in patients with a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) [31, 43]

The ratio of fat-mass loss to lean-mass loss was similar to that reported in lifestyle-based intervention in the Look AHEAD trial (241) and surgical treatment for obesity (242)

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Some patients prefer evening injections to minimize nausea awareness during sleep or to avoid appetite suppression during busy work hours

T3 suppression on GLP-1 / GIP / glucagon agonism caloric deficit and hepatic energy expenditure together downregulate T4-to-T3 conversion

These are remarkable response rates at a relatively moderate dose