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(Part II) Integrative Med Clin J

The augmentation of mitochondrial functionality, alterations in intracellular GSH concentrations, and elevation of c-glutamyl transpeptidase activity collectively facilitated the physiological amplification of androgens, leading to the potentiation of OS in LNCaP human prostate cancer cells that are responsive to androgens (81)

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51 Additionally, GSTs catalyze the S-glutathionylation of critical cysteine residues within the kinase domain, a post-translational modification that can impact kinase activity, subcellular localization, and downstream signaling cascades

Epub 2011 Jul 27