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IGF-I has been associated with the activation of the MAPK and PI3K signaling pathways (64)

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improving body composition, and elevating IGF-1 levels

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And prostaglandin E2 (PGE2) could promote the pro-inflammatory M1-like macrophage polarization, which refers to the killer-polarization state in which macrophages exert the cell cytotoxic function and IL-8 could recruit the neutrophils (27)

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