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Wegovy HD 7.2 mg, the recently approved higher-dose version of semaglutide, shows a similar dose-dependent increase, with dysesthesia reported in roughly 22% of people at that dose compared to about 6% at the standard 2.4 mg dose
The other thing is that patients with diabetes may have autonomic dysfunction, thats a known complication of diabetes, so they dont regulate blood pressure well
The trade-offs: higher cost, less dose flexibility, and dependence on manufacturer supply
Ultimate results may take one to two years to manifest as swelling dissipates and the tissues settle
CMAJ Canadian Med Assoc J 172(9):11991209
But after every attempt, I always regained the weight I lost, plus more
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