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The 2023 SURMOUNT-1 trial tested tirzepatide at 5 mg, 10 mg, and 15 mg weekly doses but did not include split-dosing arms (Jastreboff et al., NEJM 2022)

*Compounded medications are not reviewed by the FDA for safety or efficacy and are only available to patients for whom a licensed prescriber has determined your unique medical needs cannot be met by commercially available pharmacotherapies.

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Many providers suggest taking it with a large glass of water and perhaps a small, bland snack to help the pill pass through the stomach more comfortably

Unpaid dementia caregiving was valued at $446.3 billion in 2025