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Third, despite formal risk of bias assessment, differences in trial duration, participant characteristics, and outcome reporting could still have influenced treatment effects

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It is a biological override switch designed to keep you full for 8-10 hours

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In the context of GLP-1 co-activation (which prevents the blood sugar elevation that isolated glucagon would cause), the net result is increased energy expenditure without hyperglycemia

Specific psychiatric considerations include the possibility of worsening active suicidal ideation as well as impacting certain eating disorder symptomology