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As a result, phosphocreatine donates its phosphate to ADP to restore ATP for cellular functions, allowing creatine in the cytosol to diffuse back into the mitochondria for transport of the next phosphate farther from its production site

Richards HL, Ray DW, Kirby B, et al

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First characterized by Sikiric et al

If someone has certain genetic mutations, these conversion processes may not function efficiently, making it difficult for cells to absorb and use vitamin B12 effectively