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That discovery, coupled with recent federal approvals for obesity treatment, helped propel them into the mainstream

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diabetes approval anticipated later in 2026 Not yet approved in Canada: but worth knowing about now If you've ever wished the GLP-1 medications that have transformed diabetes care could come in a simple daily pill, without needles, refrigeration, or strict timing around meals, you may be closer to that reality than you think

M1-like macrophages amplify ferroptotic pressure through ferritinophagy-mediated release of labile Fe + , increased transferrin receptor (TfR1) expression, and restricted ferroportin activity, thereby enriching the tumor microenvironment (TME) with redox-active iron (71)

This results in esophageal dysmotility and inflammation