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Active or recent malignancy is a contraindication in my view until data says otherwise

This is why it's considered safe and is approved for use in products across global regulatory frameworks, including India's CDSCO, the EU, and the US FDA

Vignane, T

10.1155/2014/909657 Biomed Res

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Symptoms include seizures, arrhythmias, low blood pressure, severe muscle contraction (tetany), and death.[230] In a recent review of 10 cases, the elderly patients had been taking PPIs for an average of 8.3 yrs.[226] They suffered from severe symptoms of low magnesium and there was significant morbidity related to fatigue, unsteadiness, severe muscle contraction, seizures, cardiac arrhythmias, and multiple hospitalizations