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However, in 2006 it became clear that GIP(3-42) does not function as a physiological antagonist in vivo as its maximal circulating levels are insufficient to elicit antagonistic effects (48)

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Integrative genome-wide association studies (GWAS) and meta-analyses have identified the genetic variants in PNPLA3, TM6SF2 and MBOAT7 as key factors associated with increased liver injury risk and severity of MASLD [277, 278]

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Type 2 diabetes diagnosed before pregnancy (pre-existing diabetes) requires more intensive preconception planning, earlier medication changes, and enhanced antenatal monitoring compared to gestational diabetes, which develops during pregnancy

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