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However, the NADPH-oxidase activity (which also uses NADPH as a cofactor) is increased (producing H 2 O 2 ) during active vitiligo, therefore increasing ROS and promoting an active competition with EAS enzymes for NADPH molecules, a molecule already reduced in active vitiligo patients (Shajil and Begum, 2006)

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Cellular senescence or stemness: hypoxia flips the coin

The lyophilization process is designed for one primary reason: long-term stability

Ensure you keep the medication refrigerated as instructed and only draw it up when youre ready to inject