[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Weghuber D., Barrett T., Barrientos-Prez M., Gies I., Hesse D., Jeppesen O.K., Kelly A.S., Mastrandrea L.D., Srrig R., Arslanian S., et al
The therapeutic approach for HCC remains focused on curative treatments for early stages (resection, ablation, transplantation) or palliative systemic therapies for advanced disease (tyrosine kinase inhibitors [TKIs] and VEGF inhibitors) and immunotherapies (i.e., programmed death 1 [PD-1]/programmed cell death-ligand 1 [PD-L1] inhibitors and anti-cytotoxic T-lymphocyte-associated protein 4 [CTLA-4] antibodies) (Sadagopan et al., 2024
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Hence, this process is termed the lactate shuttle [100]
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