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Folia Med Cracoviensia

Here, we have compared the glucagonostatic effects of GLP-1(736) and (936) in vitro using physiological (pmol/l) concentrations of the peptides and over a wider range of glucose concentrations in isolated mouse and human islets (some from donors with type 2 diabetes) and extend these data to the in vivo situation with a particular focus on the counterregulatory increase in plasma glucagon during insulin-induced hypoglycaemia

Kohno H, Tanaka T, Kawabata K, Hirose Y, Sugie S, Tsuda H, Mori H

In these situations, lower-dose strategies may be explored as a tolerance-focused approach rather than a method intended to maximize metabolic effect