Someone starting at 300 pounds might lose 45 pounds (15%), while someone starting at 180 pounds might lose 27 pounds (15%)
Severe complications include acute pancreatitis (confirmed by elevated lipase and amylase), acute kidney injury from dehydration, thyroid dysfunction, and hypoglycemia if combined with other diabetes medications
10.1111/j.1360-0443.2009.02564.x 22 Cunha-OliveiraT.RegoA
Top-line data are expected in early 2026, and those completing HERO may choose to enter an open-label extension study in which all participants will receive ARD-101
"Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone--a pilot study"
Losing weight gradually reduces the risk of future regain, helps to protect muscle mass, and may allow for a more gradual change in our appearance, which may reduce the challenge in adapting to the physical changes we experience during weight loss