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Importantly, it was shown that peroxiredoxin-2 (PRDX2), an antioxidant enzyme, forms a replisome-associated ROS sensor to regulate the replication machinery (Somyajit et al., 2017), pointing out the relevance of the redox signaling/antioxidant status in dNTP synthesis and DNA replication

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Elevated SUA activates endothelial NF-B signaling, upregulating monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule-1 (ICAM-1) expressions to accelerate atherosclerosis progression (Wang H

These include 3 : Damaging proteins and cell membranes , interfering with normal cellular function