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While both forms can be used as a supplement, ALCAR is often preferred due to its ability to cross the blood-brain barrier allowing it to interact with nerves in the brain, and also donate its acetyl molecule, a key step in neurotransmitter formation, required for healthy brain activity

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In the human body, the major intracellular derivative of thiamine is its diphosphorylated form, thiamine diphosphate (ThDP)

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Journal of Applied Physiology, 120 (2), 216-225

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