4.1 Revisiting classical pathways: context-dependent roles of Nrf2 and HDAC inhibition SFN activates the Nrf2 pathway through covalent modification of specific cysteine residues (Cys151, Cys273, and Cys288) on the Keap1 protein, leading to Nrf2 stabilization, nuclear translocation, and transcriptional activation of cytoprotective genes including NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutathione biosynthesis enzymes (63)
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Jacquier-Sarlin and Polla, 1996
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Genomics 15, 493501 (2005)
The transcriptional regulator STAT3 elicits PINK1-dependent mitophagy, which eliminates dysfunctional mitochondria, reverses the collapse of the mitochondrial membrane potential, and represses mtROS release and NLRP3 inflammasomes, whilst STAT3 downregulation protects against osteoclastogenesis (156)
