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Tingley, Sex differences in GLP-1 signaling across species

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In summary, we identify thiol-disulphide exchange reactions to be an important insulin clearance mechanism and find that stabilising insulin icodec towards this reaction significantly contributes to its long pharmacokinetic/pharmacodynamic profile

As tirzepatide reduces appetite and food intake, some patients inadvertently consume less fluid, which can compromise skin moisture levels

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Table 2 Peptide concentrations (M) evaluated in the IVIP assay