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CJC-1295 Backbone Clinical Data Relevant to the No-DAC Research Profile Two randomised, placebo-controlled, double-blind, ascending-dose clinical trials of CJC-1295 DAC which shares the same tetrasubstituted GHRH backbone as the no-DAC variant produced dose-dependent increases in mean plasma GH concentrations of 2 to 10-fold for 6 days or more, and mean IGF-1 concentrations of 1.5 to 3-fold for 911 days

10.1016/j.jhep.2019.02.014 60

For this purpose, 180 mg DCC and 150 mg NHS were dissolved in 36 ml of a solution containing dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) in a ratio of 13

10.1007/s00289-022-04478-7 256 RahnamaeeS

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Blood-brain barrier penetration: Unlike many peptides, Dihexa is orally bioavailable and able to cross the blood-brain barrier, giving it direct access to the central nervous system