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Modulacin de metaloproteinasas (MMP) : balance entre MMP-1/MMP-2 y sus inhibidores TIMP, favoreciendo remodelacin ordenada de matriz cicatricial

doi: 10.1111/j.1463-1326.2011.01483.x 25 BianchiFDuqueALRFSaadSMISivieriK

Treatment with acmopatide showed a dose-dependent reduction in body weight, with decreases reaching up to 6.67%

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Peer review Peer review information Nature Reviews Molecular Cell Biology thanks Charles Brenner, Evandro Fang and Lindsay Wu for their contribution to the peer review of this work

In addition, PEGylation reduces the clearance of protein drugs by reticuloendothelial tissue, shields antigenic determinants, reduces immune system recognition, and prevents degradation by proteolytic enzymes