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These typically include nausea, vomiting, diarrhoea, constipation, abdominal discomfort, and reduced appetite
First, although we identified significant alterations in pathways such as fatty acid -oxidation and PPAR signaling, we lacked direct functional validation through experiments such as mitochondrial respiration assays, gene expression analysis of key regulators (e.g., PPAR target genes), or isotopic tracing of fatty acid oxidation
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These guidelines are the current best practice for the management of WD from the EASL
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