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In a randomized, placebo-controlled study, pemvidutide, a dual GLP-1/GCG receptor agonist, significantly decreased liver fat content by up to 68.5% after 12 weeks of treatment, accompanied by reductions in hepatic inflammation markers and body weight, highlighting the potential of dual receptor agonists to modify MASLD pathophysiology (47)

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For Fitzpatrick III-V skin, the anti-inflammatory mechanism of GHK-Cu is an active clinical advantage, reducing the inflammatory response that can lead to post-inflammatory hyperpigmentation in darker skin tones