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Among them, diacylglycerol activates PKC and impairs IRS-1 activation, while ceramides activate protein kinase C zeta (PKC) and protein phosphatase 2A (PP2A), resulting in dephosphorylation of Akt, 31,32 and promoting gluconeogenesis

Log (homeostasis model assessment-insulin-insulation resistance) Log (HOMA-IR) is useful for assessment of IR

References 1 AbavisaniM.KhoshrouA.ForoushanS

Since GHR expression in the kidney is unaltered in T1DM, elevated circulating GH-concentrations can impact on the kidney

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