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10.1016/j.tem.2008.10.003 [DOI] [PubMed] [Google Scholar] 24.Savini I, Catani MV, Evangelista D, Gasperi V, Avigliano L

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Conversely, the increase of both BDNF and proBDNF during withdrawal may represent a sign of a non-neurodegenerative process, putatively ascribed to the activation of stress-response systems (e.g., the extended amygdala)

Additionally, studies have found that the IGF-1 LR3 peptide inhibits protein breakdown, preserving muscle mass during periods of intense training or caloric deficits (3)