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They enhance autophagy and reduce lipotoxicity-induced hepatocyte apoptosis, thereby preserving the integrity of liver parenchyma (12)

Gastrointestinal side effects were mostly mild to moderate, with the highest incidence in the 8 mg fast escalation group [114]

Yang E, van Nimwegen E, Zavolan M et al (2003) Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes

Notably, retatrutide trials showed an overwhelming clearance of liver fat, with some cohorts experiencing up to an 80% reduction in hepatic lipid content, presenting a massive benefit for individuals dealing with metabolic dysfunction-associated steatotic liver disease (MASLD)

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