Nature Metabolism, 6 (3), 433
In the phase 2 trial, participants started at 4 mg without escalation experienced significantly more adverse events than those who began at 2 mg
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The group concluded that considering its substrate specificity and expression in organs such as the brain, kidney and intestine, genetic variations in may be an important contributor to inter-individual variability in drug disposition and central nervous system entry of OATP1A2 substrate drugs (Lee et al
In situations where the FOXO4 protein is bound to p53, there is a tentative observation that p53 is prevented from binding to DNA, inhibiting the process of apoptosis and allowing cells to avoid programmed death