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Scientific discussion surrounding SLU-PP-332 commonly highlights its relevance within models of cellular energy regulation and transcriptional control

In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

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Other mechanisms for the generation of hydroxyl radicals are the Fenton and/or Haber-Weiss reaction (Fagali et al

20 KimD.-W.JungT.-S.NamS.-H.KwonH.-R.KimA.ChaeS.-H.et al (2009)