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In resolved mice, UPEC initially form intracellular bacterial communities in the superficial facet cells, similar to that in adult nave mice, but they are rapidly shed within the first 6 h of infection via enhanced TNF-mediated inflammation 7

This cascade mediates the production of inositol 1,4,5-trisphosphate (IP 3 ), which stimulates calcium (Ca 2+ ) release from the sarcoplasmic reticulum, and diacylglycerol (DAG), which activates protein kinase C (PKC)

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Sikiric et al., 2018), and its role in the braingut and gutbrain axis (Sikiric et al., 2016), along with its CNS-disturbances therapy (Sikiric et al., 2016) and stress disorders (Sikiric et al., 2017

It also supports cellular detoxification processes by aiding the liver in breaking down and eliminating toxins

Its ability to lower LDL cholesterol, manage blood pressure, reduce inflammation, and improve circulation makes it a useful natural medicine for preventing cardiovascular disease