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PVN-cannulated Glp1r OBhM3Dq mice were PVN-infused with Bicuculline Methiodide (Sigma-Aldrich

Front Pharmacology

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From a pharmacokinetic perspective, besides increased gastric emptying, obesity has been suggested to modulate CYP gene expression, and increased fat mass may result in an increased Vd of lipophilic drugs

However, in contrast to GIPR agonism 14 , we find that GIPR antagonism fully retains its body weight and food intake reducing effects in mice with Vgat-Cre -mediated deletion of Gipr in GABAergic neurons, as well as in mice with loss of Gipr in peripherin-expressing neurons of the peripheral nervous system (PNS)