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More importantly, in combination with its NIR-II emission and GSH-specific activation characteristics, the probe LJ-GSH demonstrated promising capabilities for the precise localization of subcutaneous tumors and lung metastatic lesions, achieving the accurate removal of tumors with negative margins as small as 0.2 mm in diameter

Biochem Zeitschr 1924

We previously produced the App NL-G-F/NL-G-F -KI ( App NL-G-F ) mouse strain using genomic DNA of introns 15 to 17 of mouse APP, which humanized the A sequence, and introduced KM670/671NL (Swedish), I716F (Iberian), and E693G (Arctic) mutations 41

Cumulative receptor saturation occurs when IGF-1 LR3 is dosed before prior clearance, producing an anabolic ceiling where additional IGF-1 binding no longer increases mTOR activation and instead drives glucose into adipose tissue

M.De-RegilL

Metzler B, Gfeller P, Guinet E